Product Name:

4-Chlorophenol

Synonyms:

chlorophenols,solid;p-Chlorfenol;
p-chlorfenol(czech);p-chlorophenicacid;
p-chloro-pheno; Phenol, 4-chloro-; Phenol, p-chloro-

CAS:

106-48-9

MF:

C6H5ClO

MW:

128.56

EINECS:

203-402-6

Product Categories:

PhenolsAnalytical Reagents;Waste Water;Water Test;Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Potable- &;Waste Water;Waste-Water Testing;Analytical Reagents;Analytical/Chromatography;alcohol| alkyl chloride;Aromatic Phenols;Organics;Chloride chemicals;Alpha sort;C;CAlphabetic;CH;Pesticides&Metabolites;Volatiles/ Semivolatiles;Organic Building Blocks;Oxygen Compounds;Phenols;ARIMIDEX;API;intermediates;Halogenated Heterocycles

Mol File:

106-48-9.mol

Melting point 

40-45 °C(lit.)

Boiling point 

220 °C(lit.)

Density 

1.306 g/mL at 25 °C(lit.)

Vapor density 

4.43 (vs air)

Vapor pressure 

1 mm Hg ( 49.8 °C)

Refractive index 

1.5579

Fp 

240 °F

Storage temp. 

0-6°C

Solubility 

ethanol: soluble50mg/mL, clear to very slightly hazy,
colorless to faintly brownish-yellow

pka

9.18(at 25℃)

Appearance

White to pale yellow Low Melting Crystalline Mass

Odor

Phenolic like 30 ppm

Odor Threshold

30 ppm

Water Solubility 

2.7 g/100 mL (20 ºC)

Sensitive 

Air Sensitive

Stability:

Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents, iron.

Hazard Codes 

Xn,N

Risk Statements 

20/21/22-51/53-50

Safety Statements 

28-61-28A-24/25-60-36/37

RIDADR 

UN 2020 6.1/PG 3

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

 2908191000

Hazardous Substances Data

106-48-9(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 0.67 g/kg (Deichmann)

Chemical Properties

off-white to light tan crystals or powder

Chemical Properties

All isomers have a characteristic odor.

Uses

1. Intermediates of Liquid Crystals

2. antineoplastic

3. Biocide; disinfectant for home, hospital and farm.

Definition

A monochlorophenol substituted at the pare position by a chlorine atom.

General Description

White crystals with a strong phenol odor
Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible.
Used as an intermediate in organic synthesis of dyes and drugs.

Air & Water Reactions

Slightly soluble to soluble in water.

Reactivity Profile

CHLOROPHENOLS, SOLID are incompatible with acid chlorides, acid anhydrides and oxidizing agents. Also incompatible with iron . Liquefy and darken in color at temperatures above 108°F.

Hazard

Toxic by skin absorption, inhalation, or ingestion; strong irritant to tissue.

Health Hazard

Inhalation causes headache, dizziness, weak pulse. Ingestion causes irritation of mouth and stomach; headache, dizziness, weak pulse. Contact with eyes causes severe irritation and burning. Contact with skin causes irritation and burn; if absorbed, causes same symptoms as inhalation.

Fire Hazard

Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride and chlorine gases may form in fires.

Safety Profile

Poison by inhalation and intraperitoneal routes.
Moderately toxic by ingestion, skin contact, and subcutaneous routes.
A severe skin and eye irritant.
Human systemic effects by inhalation: excitement, irritability.
Mutation data reported. Combustible when exposed to heat or flame.
To fight fire, use water, spray, mist, fog, foam, dry chemical.
When heated to decomposition it emits toxic fumes of Cl-.
See also CHLOROPHENOLS and CHLORIDES.

Potential Exposure

Monochlorophenols are used in the manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction of certain minerals from coal; as a denaturant for ethanol; as an antiseptic; as a disinfectant, and others.

Shipping

UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid,
Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Distill the phenol, then crystallise it from pet ether (b 40-60o) or hexane, and dry it under vacuum over P2O5 at room temperature.

Incompatibilities

May form explosive mixture with air.
Contact with oxidizing agents can cause fire and explosion hazard.
Heat produces hydrogen chloride and chlorine.
Corrosive to aluminum, copper and other chemically active metals.

Waste Disposal

Incinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber.

Preparation Products

Triadimefon-->1,4-Dihydroxyanthraquinone-->2,6-DIFORMYL-4-CHLOROPHENOL-->5-chloro-m-xylene-2,alpha,alpha'-triol -->2-(2-CHLOROETHOXY)-BENZENESULFONAMIDE-->4-CHLOROPHENOXYACETYL CHLORIDE-->
Triadimenol-->4-Chlorophenoxyacetic acid-->3,4'-Dichlorodiphenyl ether
-->4-CHLOROPHENETOLE-->Chlorzoxazone-->Dichlorophen-->
ALUMINUM CLOFIBRATE

Raw materials

Phenol-->Sulfuryl chloride-->2,4-Dichlorophenol-->
2-Chlorophenol-->p-Dichlorobenzene